Association of Serum Adiponectin with Cardiac Enzymes in Diabetic Patients Having Coronary Heart Disease: Original Article

Sadaf Durrani; Ubaid ur Rahman; Ubaidullah; Naheed Khattak; Safiyya Ubaidullah

doi:10.64911/fmtdxg77

Authors

Sadaf Durrani Associate Professor, Department of Biochemistry, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan Author
Ubaid ur Rahman Professor, Department of Biochemistry, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan Author
Ubaidullah Associate Professor, Department of Biochemistry, Kabir Medical College, Gandhara University, Peshawar, Khyber Pakhtunkhwa, Pakistan Author
Naheed Khattak Professor, Department of Biochemistry, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan Author
Safiyya Ubaidullah Demonstrator, Department of Biochemistry, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan Author

DOI:

https://doi.org/10.64911/fmtdxg77

Keywords:

Adiponectin, Troponin I, Type 2 diabetes Mellitus, Coronary heart disease, creatinine kinase, lactate dehydrogenase

Abstract

Objective: To determine serum adiponectin levels and assess their relationship with cardiac enzymes in patients with type 2 diabetes and coronary heart disease.

Methodology: This cross-sectional analytical study was conducted in the Cardiac Care Unit of Hayatabad Medical Complex, Peshawar, from October 2025 to March 2026. The study included 60 patients with type 2 diabetes mellitus presenting with a first myocardial infarction and 60 age- and sex-matched control subjects. We measured serum adiponectin and troponin I using ELISA kits, and CK, LDH, and ALT using a Micro Lab Analyzer. We analyzed the collected data using SPSS version 21. We used independent-samples t-tests to compare groups and Pearson correlations to assess associations. We considered p < 0.05 statistically significant.

Results: Serum adiponectin levels were significantly lower in cases (3.2±1.1 vs. 11.7±2.6 µg/mL, P < 0.0001). All cardiac enzymes were significantly higher in cases: Troponin I (15.7±14.6 ng/mL vs. 0.014±0.02 ng/mL) and CK (389±43.36 vs. 165±6.78 U/L). LDH (474.54±40.53 vs 321.59±28.9 U/L) and ALT (115.28±25.63 vs 45.37 ± 14.6 U/L). We observed a negative correlation between adiponectin and troponin I (r = –0.62, p<0.001) and CK (r = –0.54, p<0.001).

Conclusion: Serum adiponectin is significantly low in type 2 diabetic patients with coronary heart disease (CHD) and is associated with significantly high cardiac enzymes in these cases with myocardial infarction. Adiponectin may serve as a protective biomarker in diabetic coronary heart disease.